Publications
(#: equal contribution, *: corresponding author. Full list | Google Scholar)
Published
Preprint
2026
Fenghe Tang,
Chengqi Dong,
Wenxin Ma,
Zikang Xu,
Heqin Zhu,
Zihang Jiang,
Rongsheng Wang,
Yuhao Wang,
Chenxu Wu,
Shaohua Kevin Zhou
[url]
BibTeX
@inproceedings{tang2025u,
title={U-Bench: A Comprehensive Understanding of U-Net through 100-Variant Benchmarking},
author={Tang, Fenghe and Dong, Chengqi and Ma, Wenxin and Xu, Zikang and Zhu, Heqin and Jiang, Zihang and Wang, Rongsheng and Wang, Yuhao and Wu, Chenxu and Zhou, Shaohua Kevin},
booktitle={Advances in Neural Information Processing Systems},
year={2026},
url={https://arxiv.org/abs/2510.07041}
}
NC-Bench and NCfold: A Benchmark and Closed-Loop Framework for RNA Non-Canonical Base-Pair Prediction
Heqin Zhu#,
Ruifeng Li#,
Ao Chang,
Mingqian Li,
Hongyang Chen*,
Peng Xiong*,
Shaohua Kevin Zhou*
[bioRxiv]
[code]
[page]
[poster]
BibTeX
@inproceedings{zhu2026nc,
title={NC-Bench and NCfold: A Benchmark and Closed-Loop Framework for RNA Non-Canonical Base-Pair Prediction},
author={Zhu, Heqin and Li, Ruifeng and Chang, Ao and Li, Mingqian and Chen, Hongyang and Xiong, Peng and Zhou, Shaohua Kevin},
booktitle={International Conference on Learning Representations},
volume={2026},
pages={135816--135832},
year={2026}
}
Heqin Zhu,
Jiaqi Wang,
Weibo Zhao,
Yuzhi Xu,
Huang Su,
Jianmin Wang,
Qinghan Wang,
Yuntao Yu,
Ziyi You,
Gang Du,
Pheng Ann Heng*,
Liqin Zhang*,
Odin Zhang*
[url]
BibTeX
@article{zhu2026nacraft,
title={NACraft: Programmatic nucleic-acid aptamer design via all-atom structure-model feedback},
author={Zhu, Heqin and Wang, Jiaqi and Zhao, Weibo and Xu, Yuzhi and Su, Huang and Wang, Jianmin and Wang, Qinghan and Yu, Yuntao and You, Ziyi and Du, Gang and Heng, Pheng Ann and Zhang, Liqin and Zhang, Odin},
journal={bioRxiv},
pages={2026--08},
year={2026},
publisher={Cold Spring Harbor Laboratory},
url={https://www.biorxiv.org/content/early/2026/08/18/2026.08.15.744087},
doi={10.64898/2026.08.15.744087}
}
Ao Chang#,
Heqin Zhu#,
Haobin Chen,
Chenxi Wang,
Xin Wang,
Xiaoyu Zeng,
Yilin Ding,
Peng Xiong*,
Shaohua Kevin Zhou*
[url]
BibTeX
@article{chang2026retif,
title={ReTIF: Granularity-Aware Multitask Interaction Routing for RNA-Compound Interaction Prediction and Binding-Site Localization},
author={Chang, Ao and Zhu, Heqin and Chen, Haobin and Wang, Chenxi and Wang, Xin and Zeng, Xiaoyu and Ding, Yilin and Xiong, Peng and Zhou, Shaohua Kevin},
journal={bioRxiv},
pages={2026--09},
year={2026},
publisher={Cold Spring Harbor Laboratory},
url={https://www.biorxiv.org/content/early/2026/09/06/2026.09.02.748859},
doi={10.64898/2026.09.02.748859}
}
Haobin Chen,
Ao Chang,
Heqin Zhu,
Rundong Wang,
Ting Liu,
Shaohua Kevin Zhou
[url]
BibTeX
@article{chen2026marr,
title={MARR: Decoupling Policy, Execution, and Calibration for All-in-One Medical Image Restoration},
author={Chen, Haobin and Chang, Ao and Zhu, Heqin and Wang, Rundong and Liu, Ting and Zhou, Shaohua Kevin},
journal={arXiv},
year={2026},
url={https://arxiv.org/abs/2609.06645}
}
Yiling Zhou#,
Yilin Wang#,
Jianmin Wang,
Heqin Zhu,
Zirui Wang,
Chang-yu Hiesh,
Kejun Ying,
Jiaqi Wang*,
Yuzhi Xu*,
Tingjun Hou*,
Odin Zhang*
[url]
BibTeX
@article{zhou2026admet,
title={ADMET-EvO: a self-evolving scientific agent for sustained research across heterogeneous tasks},
author={Zhou, Yiling and Wang, Yilin and Wang, Jianmin and Zhu, Heqin and Wang, Zirui and Hiesh, Chang-yu and Ying, Kejun and Wang, Jiaqi and Xu, Yuzhi and Hou, Tingjun and Zhang, Odin},
journal={arXiv},
year={2026},
url={https://arxiv.org/abs/2609.10121}
}
Valhalla Team
[url]
BibTeX
@article{team2026leveraging,
title={Leveraging secondary-structure information for accurate nucleic acid structure prediction with OFoldNA},
author={Team, Valhalla},
journal={arXiv},
year={2026},
url={https://arxiv.org/abs/2609.37414}
}
Haobin Chen,
Ao Chang,
Rundong Wang,
Zhicheng Li,
Zhihao Tang,
Heqin Zhu
[url]
BibTeX
@article{chen2026lassnet,
title={LASSNet: Level-Aware Availability-Conditioned Spatial-Semantic Fusion for Brain Tumor Segmentation with Missing MRI Modalities},
author={Chen, Haobin and Chang, Ao and Wang, Rundong and Li, Zhicheng and Tang, Zhihao and Zhu, Heqin},
journal={arXiv},
year={2026},
url={https://arxiv.org/abs/2609.06733}
}
Valhalla Team
[url]
BibTeX
@article{team2026novo,
title={De novo design of monoclonal and bispecific antibodies with OFAntibody},
author={Team, Valhalla},
journal={arXiv},
year={2026},
url={https://arxiv.org/abs/2610.09548}
}
Xin Wang,
Heqin Zhu,
Hao Li,
Ao Chang,
Feng Zhang,
Haobin Chen,
Chenxi Wang,
Ke Chen,
Shaohua Kevin Zhou,
Peng Xiong
[url]
BibTeX
@article{wang2026ligrna,
title={LigRNA: High-accuracy prediction of RNA-ligand binding sites via dynamic chemical complementarity and language model encoding},
author={Wang, Xin and Zhu, Heqin and Li, Hao and Chang, Ao and Zhang, Feng and Chen, Haobin and Wang, Chenxi and Chen, Ke and Zhou, Shaohua Kevin and Xiong, Peng},
journal={bioRxiv},
pages={2026--10},
year={2026},
publisher={Cold Spring Harbor Laboratory},
url={https://www.biorxiv.org/content/10.64898/2026.10.15.759315v1},
doi={10.64898/2026.10.15.759315}
}
Zhiqi Lv,
Duofan Tu,
Jun Li,
Mingyue Zhao,
Heqin Zhu,
Wenliang Li,
Shaohua Kevin Zhou
[url]
BibTeX
@article{lv2026thinking,
title={Thinking Like a Clinician: A Cognitive AI Agent for Clinical Diagnosis via Panoramic Profiling and Adversarial Debate},
author={Lv, Zhiqi and Tu, Duofan and Li, Jun and Zhao, Mingyue and Zhu, Heqin and Li, Wenliang and Zhou, Shaohua Kevin},
journal={arXiv},
year={2026},
url={https://arxiv.org/abs/2604.23605}
}
2025
Deep generalizable prediction of RNA secondary structure via base pair motif energy
Heqin Zhu,
Fenghe Tang,
Quan Quan,
Ke Chen,
Peng Xiong*,
Shaohua Kevin Zhou*
[paper]
[code]
[poster]
[poster2]
[PyPI]
BibTeX
@article{zhu2025deep,
title={Deep generalizable prediction of RNA secondary structure via base pair motif energy},
author={Zhu, Heqin and Tang, Fenghe and Quan, Quan and Chen, Ke and Xiong, Peng and Zhou, Shaohua Kevin},
journal={Nature Communications},
volume={16},
number={1},
pages={5856},
year={2025},
publisher={Nature Publishing Group UK, London}
}
A fully open structure-guided RNA foundation model for robust structural and functional inference
Heqin Zhu#,
Ruifeng Li,
Ao Chang,
Haobin Chen,
Feng Zhang,
Fenghe Tang,
Tong Ye,
Xin Li,
Yunjie Gu,
Peng Xiong*,
Shaohua Kevin Zhou*
[bioRxiv]
[code]
[PyPI]
BibTeX
@article{zhu2025fully,
title={A fully open structure-guided RNA foundation model for robust structural and functional inference},
author={Zhu, Heqin and Li, Ruifeng and Chang, Ao and Chen, Haobin and Zhang, Feng and Tang, Fenghe and Ye, Tong and Li, Xin and Gu, Yunjie and Xiong, Peng and Zhou, Shaohua Kevin},
journal={bioRxiv},
pages={2025--08},
year={2025},
publisher={Cold Spring Harbor Laboratory}
}
IRESeek: structure-informed deep learning method for accurate identification of internal ribosome entry sites in circular RNAs
Feng Zhang#,
Heqin Zhu#,
Jiayin Gao,
Jie Hu,
Ke Chen,
Shaohua Kevin Zhou*,
Peng Xiong*
[paper]
[code]
BibTeX
@article{zhang2025ireseek,
title={IRESeek: structure-informed deep learning method for accurate identification of internal ribosome entry sites in circular RNAs},
author={Zhang, Feng and Zhu, Heqin and Gao, Jiayin and Hu, Jie and Chen, Ke and Zhou, Shaohua Kevin and Xiong, Peng},
journal={NAR Genomics and Bioinformatics},
volume={7},
number={4},
pages={lqaf210},
year={2025},
publisher={Oxford University Press}
}
2024
Pele scores: pelvic x-ray landmark detection with pelvis extraction and enhancement
Zhen Huang#,
Han Li#,
Shitong Shao,
Heqin Zhu,
Huijie Hu,
Zhiwei Cheng,
Jianji Wang,
Shaohua Kevin Zhou
BibTeX
@article{huang2024pele,
title={Pele scores: pelvic x-ray landmark detection with pelvis extraction and enhancement},
author={Huang, Zhen and Li, Han and Shao, Shitong and Zhu, Heqin and Hu, Huijie and Cheng, Zhiwei and Wang, Jianji and Zhou, Shaohua Kevin},
journal={International Journal of Computer Assisted Radiology and Surgery},
volume={19},
number={5},
pages={939--950},
year={2024},
publisher={Springer International Publishing, Cham}
}
Which images to label for few-shot medical image analysis?
Quan Quan#,
Qingsong Yao#,
Heqin Zhu,
Qiyuan Wang,
Shaohua Kevin Zhou
[code]
BibTeX
@article{quan2024images,
title={Which images to label for few-shot medical image analysis?},
author={Quan, Quan and Yao, Qingsong and Zhu, Heqin and Wang, Qiyuan and Zhou, Shaohua Kevin},
journal={Medical Image Analysis},
volume={96},
pages={103200},
year={2024},
publisher={Elsevier}
}
Igu-aug: Information-guided unsupervised augmentation and pixel-wise contrastive learning for medical image analysis
Quan Quan#,
Qingsong Yao#,
Heqin Zhu,
Shaohua Kevin Zhou
[arXiv]
[code]
BibTeX
@article{quan2024igu,
title={Igu-aug: Information-guided unsupervised augmentation and pixel-wise contrastive learning for medical image analysis},
author={Quan, Quan and Yao, Qingsong and Zhu, Heqin and Zhou, Shaohua Kevin},
journal={IEEE Transactions on Medical Imaging},
volume={44},
number={1},
pages={154--164},
year={2024},
publisher={IEEE}
}
Hyspark: Hybrid sparse masking for large scale medical image pre-training
Fenghe Tang,
Ronghao Xu,
Qingsong Yao,
Xueming Fu,
Quan Quan,
Heqin Zhu,
Zaiyi Liu,
Shaohua Kevin Zhou
[arXiv]
[code]
BibTeX
@inproceedings{tang2024hyspark,
title={Hyspark: Hybrid sparse masking for large scale medical image pre-training},
author={Tang, Fenghe and Xu, Ronghao and Yao, Qingsong and Fu, Xueming and Quan, Quan and Zhu, Heqin and Liu, Zaiyi and Zhou, Shaohua Kevin},
booktitle={International conference on medical image computing and computer-assisted intervention},
pages={330--340},
year={2024},
organization={Springer Nature Switzerland, Cham}
}
SIX-Net: Spatial-Context Information miX-up for Electrode Landmark Detection
Xinyi Wang,
Zikang Xu,
Heqin Zhu,
Qingsong Yao,
Yiyong Sun,
Shaohua Kevin Zhou
BibTeX
@inproceedings{wang2024six,
title={SIX-Net: Spatial-Context Information miX-up for Electrode Landmark Detection},
author={Wang, Xinyi and Xu, Zikang and Zhu, Heqin and Yao, Qingsong and Sun, Yiyong and Zhou, Shaohua Kevin},
booktitle={International Conference on Medical Image Computing and Computer-Assisted Intervention},
pages={338--348},
year={2024},
organization={Springer Nature Switzerland, Cham}
}
Xiaoqian Zhou,
Zhen Huang,
Heqin Zhu,
Qingsong Yao,
Shaohua Kevin Zhou
[url]
BibTeX
@article{zhou2024hybrid,
title={Hybrid attention network: an efficient approach for anatomy-free landmark detection},
author={Zhou, Xiaoqian and Huang, Zhen and Zhu, Heqin and Yao, Qingsong and Zhou, Shaohua Kevin},
journal={arXiv},
year={2024},
url={https://arxiv.org/abs/2412.06499}
}
2023
Quan Quan,
Shang Zhao,
Qingsong Yao,
Heqin Zhu,
Shaohua Kevin Zhou
[url]
BibTeX
@article{quan2023unsupervised,
title={Unsupervised augmentation optimization for few-shot medical image segmentation},
author={Quan, Quan and Zhao, Shang and Yao, Qingsong and Zhu, Heqin and Zhou, Shaohua Kevin},
journal={arXiv},
year={2023},
url={https://arxiv.org/abs/2306.05107}
}
UOD: Universal one-shot detection of anatomical landmarks
Heqin Zhu,
Quan Quan,
Qingsong Yao,
Zaiyi Liu,
Shaohua Kevin Zhou
[paper]
[arXiv]
[code]
[poster]
BibTeX
@inproceedings{zhu2023uod,
title={UOD: Universal one-shot detection of anatomical landmarks},
author={Zhu, Heqin and Quan, Quan and Yao, Qingsong and Liu, Zaiyi and Zhou, Shaohua Kevin},
booktitle={International Conference on Medical Image Computing and Computer-Assisted Intervention},
pages={24--34},
year={2023},
organization={Springer Nature Switzerland, Cham}
}
Quan Quan#,
Fenghe Tang#,
Zikang Xu,
Heqin Zhu,
Shaohua Kevin Zhou
[url]
[code]
BibTeX
@article{quan2023slide,
title={Slide-sam: Medical sam meets sliding window},
author={Quan, Quan and Tang, Fenghe and Xu, Zikang and Zhu, Heqin and Zhou, Shaohua Kevin},
journal={arXiv},
year={2023},
url={https://arxiv.org/abs/2311.10121}
}
2022
Qingsong Yao,
Jianji Wang,
Yihua Sun,
Quan Quan,
Heqin Zhu,
Shaohua Kevin Zhou
[url]
BibTeX
@article{yao2022relative,
title={Relative distance matters for one-shot landmark detection},
author={Yao, Qingsong and Wang, Jianji and Sun, Yihua and Quan, Quan and Zhu, Heqin and Zhou, Shaohua Kevin},
journal={arXiv},
year={2022},
url={https://arxiv.org/abs/2203.01687}
}
Heqin Zhu,
Qingsong Yao,
Shaohua Kevin Zhou
[url]
BibTeX
@article{zhu2022datr,
title={Datr: Domain-adaptive transformer for multi-domain landmark detection},
author={Zhu, Heqin and Yao, Qingsong and Zhou, Shaohua Kevin},
journal={arXiv},
year={2022},
url={https://arxiv.org/abs/2203.06433}
}
Heqin Zhu,
Xu Sun,
Yuexiang Li,
Kai Ma,
Shaohua Kevin Zhou,
Yefeng Zheng*
[url]
BibTeX
@article{zhu2022dftr,
title={DFTR: Depth-supervised fusion transformer for salient object detection},
author={Zhu, Heqin and Sun, Xu and Li, Yuexiang and Ma, Kai and Zhou, Shaohua Kevin and Zheng, Yefeng},
journal={arXiv},
year={2022},
url={https://arxiv.org/abs/2203.06429}
}
Learning to Localize Cross-Anatomy Landmarks in X-Ray Images with a Universal Model
Heqin Zhu,
Qingsong Yao,
Li Xiao,
Shaohua Kevin Zhou
[paper]
[code]
BibTeX
@article{zhu2022learning,
title={Learning to Localize Cross-Anatomy Landmarks in X-Ray Images with a Universal Model},
author={Zhu, Heqin and Yao, Qingsong and Xiao, Li and Zhou, Shaohua Kevin},
journal={BME Frontiers},
volume={2022},
pages={9765095},
year={2022}
}
2021
You only learn once: Universal anatomical landmark detection
Heqin Zhu,
Qingsong Yao,
Li Xiao,
Shaohua Kevin Zhou
[paper]
[arXiv]
[code]
BibTeX
@inproceedings{zhu2021you,
title={You only learn once: Universal anatomical landmark detection},
author={Zhu, Heqin and Yao, Qingsong and Xiao, Li and Zhou, Shaohua Kevin},
booktitle={International conference on medical image computing and computer-assisted intervention},
pages={85--95},
year={2021},
organization={Springer International Publishing, Cham}
}
Deep learning to segment pelvic bones: large-scale CT datasets and baseline models
Pengbo Liu,
Hu Han,
Yuanqi Du,
Heqin Zhu,
Yinhao Li,
Feng Gu,
Honghu Xiao,
Jun Li,
Chunpeng Zhao,
Li Xiao,
Shaohua Kevin Zhou
BibTeX
@article{liu2021deep,
title={Deep learning to segment pelvic bones: large-scale CT datasets and baseline models},
author={Liu, Pengbo and Han, Hu and Du, Yuanqi and Zhu, Heqin and Li, Yinhao and Gu, Feng and Xiao, Honghu and Li, Jun and Zhao, Chunpeng and Xiao, Li and Zhou, Shaohua Kevin},
journal={International Journal of Computer Assisted Radiology and Surgery},
volume={16},
number={5},
pages={749--756},
year={2021},
publisher={Springer International Publishing, Cham}
}
A 3 DSegNet: anatomy-aware artifact disentanglement and segmentation network for unpaired segmentation, artifact reduction, and modality translation
Yuanyuan Lyu,
Haofu Liao,
Heqin Zhu,
Shaohua Kevin Zhou
BibTeX
@inproceedings{lyu20213,
title={A 3 DSegNet: anatomy-aware artifact disentanglement and segmentation network for unpaired segmentation, artifact reduction, and modality translation},
author={Lyu, Yuanyuan and Liao, Haofu and Zhu, Heqin and Zhou, Shaohua Kevin},
booktitle={International Conference on Information Processing in Medical Imaging},
pages={360--372},
year={2021},
organization={Springer International Publishing, Cham}
}